The Children's Museum of The Upstate opened in 2009. Conveniently offering reciprocal memberships in two locations, TCMU's downtown Greenville location allows visitors to experience 80,000 square feet and 19 exhibit galleries, with components and programming in the areas of arts, humanities, sciences, health, nutrition, and the environment, suitable to children ages 1-15.

TCMU's downtown Spartanburg location offers 6,000 square feet of exhibits and programs designed to support preschool children ages birth - 5. With exhibits specific to Spartanburg's landmarks, culture, and community, the museum features 7 exhibits, including a hospital exhibit, a water table with replicas of the Pacolet and Tyger Rivers, and a treehouse hosting replicas of South Carolina's native plants and birds. TCMU is the nation's 7th largest children's museum and 10th largest in the world. As the nation's first children's museum to become a Smithsonian Affiliate, there are new and exciting programs developed for every age level to stimulate creativity and stirs the imagination.